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Monday, May 21, 2012

Run Car On 100% Water


RUN YOUR CAR ON 100% WATER- YOUR THE 100TH HUMAN EFFECT :)
please share :)

Plasma arc water fuel injectors produce ionized water via a resonant frequency which is sent through the spark plug, and then passed through a plasma arc or ignited by laser. This allows the hydrogen and oxygen to be liberated, and burnt on the fly." The Hydrogen Fracturing Process dissociates the water molecule by way of resonance voltage stimulation, thus ionizes the combustible gases by electron ejection and, then, prevents the formation of the water molecule during thermal gas ignition releasing thermal explosive energy beyond "normal" gas burning levels under control state and the process is environmentally safe."

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Mahalo,

FREE ENERGY on the Way!

Free energy devises on their way :)))
Free Energy is Proven Technology

The Space Power Generator is proven technology that produces 200-300 percent over-unity energy.

"At the face of it, it sounds unbelievable, that vacuum which is considered by current scientific theories as a void or a state of nothingness can ever generate energy out of its own substratum." ~ Paramahamsa Tewari - Chief Project Engineer, Kaiga Project, Nuclear Power Corp., Karwar, India

Experiments conducted during the last 10 years have indicated that his Space Power Generator (SPG) is operating at over-unity efficiency. Many researchers have performed experiments with these devices, also called homopolar generators or unipolar dynamos. The devices usually consist of a rotating magnetic disk called a Faraday homopolar generator in which electrical current is passed from the center of the disk to its edge.

Toby Grotz, of Wireless Engineering, visited India in December of 1997 to perform an independent set of measurements of the Tewari SPG. Using calibrated high-accuracy instruments, traceable to the National Bureau of Standards, tests were conducted that confirm Tewari's measurements.

Paramahamsa Tewari made a breakthrough in a method of electrical power generation. He has been granted an Indian Patent (Application number 397/Bom/94) for an increased efficiency homopolar generator.

For details on the free energy technology :: http://www.rexresearch.com/tewari/tewari.htm

Bruce Eldridge De Palma is the son of noted orthopaedic surgeon Anthony DePalma and the elder brother of film director Brian De Palma. Bruce is a well known figure in the Free energy suppression community.

Panacea has some brief detail of this energy suppression case profiled on the energy suppresion page. His N-machine Homopolar generator is a device based on the Faraday disc and was reported to produce up to five times the energy required to run it.

After Bruce's death his research was discontinued. A close friend of Bruce, Paramahamsa Tewari had been under some instruction and was in partnership with Bruce to produce the N machines.

http://www.panacea-bocaf.org/depalmatewari.htm

Thursday, May 17, 2012

Baking Soda and Cancer

The cancer industry is closing in on baking soda and beginning to do research in earnest about sodium bicarbonate and how it is a primary tool in the treatment of fungus. Cancer is a fungus, can be caused by a fungus, or is accompanied by late-stage fungal infections, and now the Mayo Clinic confirms this. They are not the first to say so though. Many, even from the official world of orthodox oncology, recognize the similarities of cancer and fungal infections, the decay that ties these two together in a dance that all too often ends in miserable death.

The Mayo Clinic is saying that a fungal infection of the gastrointestinal tract mimics cancer and inflammatory bowel disease. The invasive fungus, Basidiobolus ranarum, is typically found in the soil, decaying organic matter and the gastrointestinal tracts of fish, reptiles, amphibians, and bats.

Patients with this fungal infection had non-specific symptoms such as abdominal pain or a mass that could be felt on examination. Before a conclusive diagnosis of the fungal infection was made, most patients were thought to have abdominal cancer, inflammatory bowel disease or diverticulitis. Surgical resection of the area of involvement and prolonged antifungal therapy successfully treated most patients.

Interestingly, a few years ago researchers at Johns Hopkins were surprised that the drug itraconazole, commonly used to treat toenail fungus, can also block angiogenesis, the growth of new blood vessels commonly seen in cancers. Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Cancer researchers studying the conditions necessary for cancer metastasis have discovered that angiogenesis is one of the critical events required for metasteses to occur. In mice induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67% compared to placebo. "We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis," says Dr. Jun O. Liu, professor of pharmacology. "We couldn't have predicted that an antifungal drug would have such a role." Itraconazole was found to reduce the numbers of circulating cancer cells, prevent the worsening of prostate cancers, and delay the need for chemotherapy. However, it has serious side effects when given in the necessary high dosages that include hypertension, low potassium levels and fluid retention. These side effects require treatment with other medications. Effects of high doses of itraconazole could lead to heart failure.

For two decades John Hopkins has recognized the increasing frequency of severe fungal infections in patients with neoplastic diseases. Most fungal infections are caused by the commonly recognized opportunistic fungi Candida spp and Aspergillus spp, and the pathogenic fungi Cryptococcus neoformans, Histoplasma capsulatum, Coccidiodes immitis, and less often by Blastomyces dermatidis. However, recently newer pathogens such as Pheohyphomycetes, Hyalohyphomycetes, Zygomycetes and other fungi of emerging importance such as Torulopsis glabrata, Trichosporon beigelii, Malassezia spp, Saccharomyces spp, Hansenula spp, Rhodotorula spp, and Geotrichum candidum have appeared as significant causes of infection in this patient population.

Dr. Tullio Simoncini does not say that cancer is caused by yeast; what he is telling the world is that the cancer is a yeast overgrowth. What causes the cancer (or a yeast-filled tumor) is another thing. Simoncini has always insisted that tumors are white because they are fungi. Some have made fun of him, but looking around at the extremely sparse information about the subject, I ran into one person saying:

"If someone had asked me a year ago what color the inside of a tumor was, I would have guessed red and gray. When they did the biopsy, I asked to see the tissue specimens: five quarter-inch to half-inch strings of vermicelli (Italian for little worms) with little streakings of blood. They didn't look evil to me, just strings of fat. The entire mass was white inside as the pathology report stated.

Specialists in throat and mouth cancer say that cancers can be red or white patches: any patch that appears randomly and is red or white in color could be a mouth cancer symptom. The white patches in the mouth are called leukoplakia and the red patches are called erythroplakia, which are pre-cancerous conditions. Though these red or white patches are not always cancerous, it could be the result of a fungal infection caused by Candida called thrush. Thrush will lead to a red patch that often bleeds after the white patch disappears. A small amount of this fungus lives in your mouth most of the time. It is usually kept in check by your immune system and other types of germs that also normally live in your mouth. However, when your immune system is weak, the fungus can grow.

Fungal Mycotoxins

It just so happens that a toxin produced by mold on nuts and grains can cause liver cancer, according to University of California Irvine Researchers. And a French case-control study of 1,010 breast cancer cases and 1,950 controls with nonmalignant diseases found that breast cancer was associated with increased frequency of mold-fermented cheese consumption. Fungi produce mycotoxins, which can kill us or cause cancer.

Dr. Wang and Groopman from the Environmental Health Sciences Department at Johns Hopkins published on the effects of mold toxins on DNA in Mutation Research, a leading cancer journal. They said mycotoxins with carcinogenic potency include aflatoxins, sterigmatocystin, ochratoxin, fumonisins, zearalenone, and some Penicillium toxins. Most of these carcinogenic mycotoxins are genotoxic agents. Aflatoxin is a potent genotoxic agent, is mutagenic in many model systems and produces chromosomal aberrations, micronuclei, sister chromatid exchange, unscheduled DNA synthesis, and chromosomal strand breaks. Most strikingly, the relationship between aflatoxin exposure and development of human hepatocellular carcinoma (liver cancer) is demonstrated by studies.

Harrison et al. (1993) examined human breast cancer tissue for evidence of the presence of aflatoxin. The researchers examined human DNA from a variety of tissues and organs to identify and quantify aflatoxin DNA-adducts. Such adducts are considered to be proof of the mycotoxin's presence in a particular tissue. Aflatoxins may in fact be a risk factor for cancer induction in a variety of organs in man, in the same manner as that of cigarette smoking.

DNA from normal and tumorous tissue obtained from patients with cancer of the breast was examined. Tumor tissues had higher aflatoxin-adduct levels than did normal tissue from the same individual. The result of this study verifies the presence of carcinogenic aflatoxin within the cancer tissue and thus implicates aflatoxin as a cause of breast cancer. That is the same as saying cancer is a fungus or is caused by a fungus and this is what Dr. Simoncini has been saying all along.

Intensive Care Units are particularly on alert with immunocompromised and oncology patients for fungal infections. "Patients with brain tumors used to have a life expectancy of 3-12 months, but better treatment has allowed them to live a bit longer," said Brenda Shelton, clinical nurse specialist at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore. "The last two brain tumor ICU patients we treated died of infection, not of their disease. One patient had a rare fungus, and the other had candidemia. Years ago, you would not see most of these fungal infections in patients with brain tumors because they would not live long enough."

"The biggest misconception is the belief that fungal infections are rare," Shelton said. "Another misconception is fungal infections are like every other severe infection. They are harder to manage, harder to eradicate and more frequent than people realize." One of the most common complications involved in treating patients with hematologic cancer is fungal infections.

Aspergillus niger fungal infection in human lungs produces large amounts of oxalic acid, which is extremely toxic to the blood vessels and which may cause fatal pulmonary hemorrhages. Consequently, oxalic acid (calcium oxalate crystals) in the sputum or lung specimens of patients is also an indication of an Aspergillus infection of the lung. These calcium oxalate crystals are the same as the calcium oxalate found in breast cancers. The presence of oxalates in the breast is indicative of the presence of fungi interwoven within the stages of breast cancer development. Since humans do not make oxalic acid themselves, this is an appropriate conclusion.

Dr. Robert Young states, "Bacteria, yeast/fungi, and mold are not the cause of a cancerous condition but are the result and the evidence of cells and tissues biologically transforming from a healthy state and to an unhealthy state." Dr. Young astutely observed that, "over-acidification of the body leads to the development of chronic yeast and fungal infections and ultimately a cancerous condition of the cells and tissues."

If one has cancer, chances are pretty good that one
also has a fungal infection to one degree or another.


According to The Home Medical Encyclopedia, in 1963 about one-half of all Americans suffered from an "unrecognized" systemic fungal condition. Far more Americans suffer from fungal infections today as antibiotics, hormone replacement therapies, and birth control pills continue to be consumed like candy. Thus more and more children are becoming infected with candidal meningitis or viral meningitis, which means their systems are suffering under the weight of fungi who put out an assortment of poisons - or mycotoxins.

Sodium Bicarbonate is an Antifungal Agent

The current controversy over sodium bicarbonate and its use in oncology might be relatively new but baking soda has a long history of helping people get through the worst medical conditions. The Eloquent Peasant, an Egyptian literary work dated around 2000 B.C., refers to a peddler selling natron, a natural blend of sodium bicarbonate, chloride and sodium carbonate used in mummification, just one of hundreds of uses this compound has been put to. Baking soda's first widespread use was probably as a leavening agent for bread and other baked goods. It has been used commercially since 1775, although the now-famous Arm & Hammer brand wasn't introduced until 1867.

Sodium bicarbonate (Na2HCO3) is recognized by most as ordinary baking soda, which is found in deposits around the globe. Its backbone characteristic is to maintain balance of carbon dioxide, bicarbonate and pH. Sodium bicarbonate is available and sold in every supermarket and pharmacy in the world and is widely used in emergency rooms and intensive care wards in injectable forms but is sold as a common household substance that is used for hundreds of different things.

Read my book, Sodium Bicarbonate, and see that something as inexpensive as baking soda will outperform the most expensive pharmaceuticals. Across a wide range of disorders, including cancer and diabetes, we find conclusive evidence and plenty of theoretical backing to suggest that sodium bicarbonate is a frontline universal medicine that should be employed by all practitioners of the healing and medical arts for a broad range of disorders that are afflicting contemporary man.

For all the references, sources and more articles, please visit Dr. Mark Sircus blog.

About the author:
About the author:
Mark A. Sircus, Ac., OMD, is director of the International Medical Veritas Association (IMVA) http://www.imva.info/.

Dr. Sircus was trained in acupuncture and oriental medicine at the Institute of Traditional Medicine in Sante Fe, N.M., and at the School of Traditional Medicine of New England in Boston. He served at the Central Public Hospital of Pochutla in Mexico, and was awarded the title of doctor of oriental medicine for his work. He was one of the first nationally certified acupuncturists in the United States. Dr. Sircus's IMVA is dedicated to unifying the various disciplines in medicine with the goal of creating a new dawn in healthcare.

He is particularly concerned about the effect vaccinations have on vulnerable infants and is identifying the common thread of many toxic agents that are dramatically threatening present and future generations of children. His book, The Terror of Pediatric Medicine, is a free e-book offered on his web site. Humane Pediatrics will be an e-book available early in 2011 and then quickly as possible put into print.

Dr. Sircus is a most prolific and courageous writer and one can read through hundreds of pages on his various web sites.

He has recently released a number of e-books including Winning the War Against Cancer, Survival Medicine for the 21st Century, Sodium Bicarbonate, Rich Man’s Poor Man’s Cancer Treatment, New Paradigms in Diabetic Care and Bringing Back the Universal Medicine: IODINE.

Dr. Sircus is a pioneer in the area of natural detoxification and chelation of toxic chemicals and heavy metals. He is also a champion of the medicinal value of minerals and seawater.

Transdermal Magnesium Therapy, his first published work, offers a stunning breakthrough in medicine, an entirely new way to supplement magnesium that naturally increases DHEA levels, brings cellular magnesium levels up quickly, relieves pain, brings down blood pressure and pushes cell physiology in a positive direction. Magnesium chloride delivered transdermally brings a quick release from a broad range of conditions. His second edition of Transdermal Magnesium Therapy will be out shortly. In addition he writes critically about the political and financial crises occurring around us.

International Medical Veritas Association: http://www.imva.info/
http://publications.imva.info/

Sunday, May 6, 2012

MSG the Slow Poison

MSG Lurks As A Slow Poison In Common Food Items Without Your Knowledge
 
The food additive "MSG" is a slow poison which hides behind dozens of names, such as natural flavouring and yeast extract. Currently, labeling standards do not require MSG to be listed in the ingredient list of thousands of foods.

MSG is not a nutrient, vitamin, or mineral and has no health benefits. The part of MSG that negatively affects the human body is the "glutamate", not the sodium. The breakdown of MSG typically consists of 78% glutamate, 12% sodium, and about 10% water. Any glutamate added to a processed food is not and can not be considered naturally occurring. Natural glutamate in plants and animals is known as L-glutamic acid. Our normal digestive process slowly breaks down this natural or "bound" glutamic acid and it is then delivered to glutamate receptors in our body and brain. Broken down this way, it is harmless. In a factory, however, the bound glutamic acid in certain foods (corn, molasses, wheat) is broken down or made "free" by various processes (hydrolyzed, autolyzed, modified or fermented with strong chemicals, bacteria, or enzymes) and refined to a white crystal that resembles sugar.

Since free glutamate can be a component part of certain food additives, such as autolyzed yeast or hydrolyzed protein, it is essentially unregulated when it comes to labeling standards. This allows it to go into food unlabeled as MSG. A label may say "yeast extract", "calcium caseinate", or "beef flavoring", but the product still contains varying amounts of "free" glutamic acid. This makes it very difficult for consumers who are trying to avoid it. It is also very dangerous for those who suffer severe reactions to it. Many people who are very sensitive to MSG experience respiratory, neurological, muscular, skin, urological and even cardiac symptoms.
So why is MSG even allowed into our food supply? Because they can get us to eat almost anything. There is such an incredible amount of disinformation in the powers that regulate and control food, that they can get us to consume things with absolutely no nutritional value at all. As long as manufacturing costs are minimized, and we keep buying their food, they'll keep making it regardless of the detriments to our health. MSG has been proven to act as an excitotoxin which stimulates the reward system of the brain, so we think it tastes better (than it actually does) and consequently consume more.

There are a growing number of Clinicians and Scientists who are convinced that excitotoxins play a critical role in the development of several neurological disorders, including migraines, seizures, infections, abnormal neural development, certain endocrine disorders, specific types of obesity, and especially the neurodegenerative diseases; a group of diseases which includes: ALS, Parkinson's disease, Alzheimer's disease, Huntington's disease, and olivopontocerebellar degeneration.
The amount of these neurotoxins added to our food has increased enormously since their first introduction. For example, since 1948 the amount of MSG added to foods has doubled every decade. By 1972, 262,000 metric tons were being added to foods.

How Excitotoxins Destroy Our Health

So, what is exactly is an excitotoxin? These are substances, usually amino acids, that react with specialized receptors in the brain in such a way as to lead to destruction of certain types of brain cells. Glutamate is a normal neurotransmitter in the brain. In fact, it is the most commonly used neurotransmitter by the brain. Defenders of MSG and aspartame use, often say: “How could a substance that is used normally by the brain cause harm?” This is because, glutamate, as a neurotransmitter, is used by the brain only in very, very small concentrations - no more than 8 to 12ug. When the concentration of this transmitter rises above this level the neurons begin to fire abnormally. At higher concentrations, the cells undergo a specialized process of cell death.

The brain has several elaborate mechanisms to prevent accumulation of MSG in the brain. First is the blood-brain barrier, a system that impedes glutamate entry into the area of the brain cells. But, this system was intended to protect the brain against occasional elevation of glutamate of a moderate degree, as would be found with un-processed food consumption. It was not designed to eliminate very high concentrations of glutamate consumed daily, several times a day, as we see in modern society. Several experiments have demonstrated that under such conditions, glutamate can by-pass this barrier system and enter the brain in toxic concentrations. In fact, there is some evidence that it may actually be concentrated within the brain with prolonged exposures. There are also several conditions under which the blood-brain barrier (BBB) is made incompetent. Before birth, the BBB is incompetent and will allow glutamate to enter the brain. It may be that for a considerable period after birth the barrier may also incompletely developed as well. Hypertension, diabetes, head trauma, brain tumors, strokes, certain drugs, Alzheimer's disease, vitamin and mineral deficiencies, severe hypoglycemia, heat stroke, electromagnetic radiation, ionizing radiation, multiple sclerosis, and certain infections can all cause the barrier to fail. In fact, as we age the barrier system becomes more porous, allowing excitotoxins in the blood to enter the brain. So there are numerous instances under which excitotoxin food additives can enter and damage the brain.

Finally, recent experiments have shown that glutamate can open the barrier itself. Another system used to protect the brain against environmental excitotoxins, is a system within the brain that binds the glutamate molecule (called the glutamate transporter) and transports it to a special storage cell (the astrocyte) within a fraction of a second after it is used as a neurotransmitter. This system can be overwhelmed by high intakes of MSG, aspartame and other food excitotoxins. It is also known that excitotoxins themselves can cause the generation of numerous amounts of free radicals and that during the process of lipid peroxidation (oxidation of membrane fats) a substance is produced called 4-hydroxynonenal. This chemical inhibits the glutamate transporter, thus allowing glutamate to accumulate in the brain. Excitotoxins destroy neurons partly by stimulating the generation of large numbers of free radicals. Recently, it has been shown that this occurs not only within the brain, but also within other tissues and organs as well (liver and red blood cells). This could, from all available evidence, increase all sorts of degenerative diseases such as arthritis, coronary heart disease, and atherosclerosis, as well as induce cancer formation. Certainly, we would not want to do something that would significantly increase free radical production in the body. It is known that all of the neurodegenerative disease, such as Parkinson's disease, Alzheimer's disease, and ALS, are associated with free radical injury of the nervous system.
It should also be appreciated that the effects of excitotoxin food additives generally are not dramatic. Some individuals may be especially sensitive and develop severe symptoms and even sudden death from cardiac irritability, but in most instances the effects are subtle and develop over a long period of time. While MSG is probably not the direct cause of the neurodegenerative diseases, such as Alzheimer's dementia, Parkinson's disease, or amyotrophic lateral sclerosis, it may well precipitate these disorders and certainly worsen their effects. It may be that many people with a propensity for developing one of these diseases would never develop a full blown disorder had it not been for their exposure to high levels of food borne excitotoxin additives. Some may have had a very mild form of the disease had it not been for the exposure.

Hydrolyzed vegetable protein should not be confused with hydrolyzed vegetable oil. The oil does not contain appreciable concentration of glutamate, it is an oil. Hydrolyzed vegetable protein is made by a chemical process that breaks down the vegetable's protein structure to purposefully free the glutamate. This brown powdery substance is used to enhance the flavor of foods, especially meat dishes, soups, and sauces. Despite the fact that some health food manufacturers have attempted to sell the idea that this flavor enhancer is " all natural" and "safe" because it is made from vegetables, it is not. It is the same substance added to processed foods. Experimentally, one can produce the same brain lesions using hydrolyzed vegetable protein as by using MSG. A growing list of excitotoxins is being discovered, including several that are found naturally. For example, L- cysteine is a very powerful excitotoxin. Recently, it has been added to certain bread dough and is sold in health food stores as a supplement. Homocysteine, a metabolic derivative, is also an excitotoxin. Interestingly, elevated blood levels of homocysteine has recently been shown to be a major, if not the major, indicator of cardiovascular disease and stroke. Equally interesting, is the finding that elevated levels have also been implicated in neurodevelopmental disorders, especially anencephaly and spinal dysraphism (neural tube defects). It is thought that this is the protective mechanism of action of the prenatal vitamins B12, B6, and folate when used in combination. It remains to be seen if the toxic effect is excitatory or by some other mechanism. If it is excitatory, then unborn infants would be endangered as well by glutamate and the other excitotoxins.

Recently, several studies have been done in which it was found that all Alzheimer's patients examined had elevated levels of homocysteine. Recent studies have shown that persons affected by Alzheimer's disease also have widespread destruction of their retinal ganglion cells. Interestingly, this is the area found to be affected when researchers first discovered the excitotoxicity of MSG. While this does not prove that dietary glutamate and other excitotoxins cause or aggravate Alzheimer's disease, it makes one very suspicious. One could argue a common intrinsic etiology for central nervous system neuronal damage and retinal ganglion cell damage, but these findings are disconcerting enough to warrant further investigations.

Truth about MSG

The Truth about MSG Monosodium Glutamate Clinical Nutrition

What effects does MSG have on diet, obesity, health and food cravings?

Because MSG is absorbed very quickly in the gastrointestinal tract (unlike glutamic acid-containing proteins in foods), MSG could spike blood plasma levels of glutamate. Glutamic acid is in a class of chemicals known as excitotoxins, high levels of which have been shown in animal studies to cause damage to areas of the brain unprotected by the blood-brain barrier and that a variety of chronic diseases can arise out of this neurotoxicity.

Dr. Vincent Bellonzi is a chiropractor and a Certified Clinical Nutritionist. He has been in practice for over 12 years. He received his Doctorate from Los Angeles College of Chiropractic in 1991.

Since 1998, Dr. Bellonzi has practiced in the Austin area. He works with athletes at every level to provide sports conditioning and rehabilitation.

Visit Dr. Bellonzi's website at
http://www.bewellrx.com
http://www.austinwellnessinstitute.com

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© Copyright 2007 Austin Wellness Institute. All Rights Reserved.

BEWARE of MSG - monosodium glutamate


Hypoxia-ischemia and retinal ganglion cell damage

Authors: Charanjit Kaur, Wallace S Foulds, Eng-Ang Ling

Published Date August 2008 Volume 2008:2(4) Pages 879 - 889
DOI: http://dx.doi.org/10.2147/OPTH.S3361

Charanjit Kaur1, Wallace S Foulds2, Eng-Ang Ling1
1Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Singapore Eye Research Institute, Singapore

Abstract: Retinal hypoxia is the potentially blinding mechanism underlying a number of sight-threatening disorders including central retinal artery occlusion, ischemic central retinal vein thrombosis, complications of diabetic eye disease and some types of glaucoma. Hypoxia is implicated in loss of retinal ganglion cells (RGCs) occurring in such conditions. RGC death occurs by apoptosis or necrosis. Hypoxia-ischemia induces the expression of hypoxia inducible factor-1α and its target genes such as vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS). Increased production of VEGF results in disruption of the blood retinal barrier leading to retinal edema. Enhanced expression of NOS results in increased production of nitric oxide which may be toxic to the cells resulting in their death. Excess glutamate release in hypoxic-ischemic conditions causes excitotoxic damage to the RGCs through activation of ionotropic and metabotropic glutamate receptors. Activation of glutamate receptors is thought to initiate damage in the retina by a cascade of biochemical effects such as neuronal NOS activation and increase in intracellular Ca2+ which has been described as a major contributing factor to RGC loss. Excess production of proinflammatory cytokines also mediates cell damage. Besides the above, free-radicals generated in hypoxic-ischemic conditions result in RGC loss because of an imbalance between antioxidant- and oxidant-generating systems. Although many advances have been made in understanding the mediators and mechanisms of injury, strategies to improve the damage are lacking. Measures to prevent neuronal injury have to be developed.

Source:  http://www.dovepress.com/hypoxia-ischemia-and-retinal-ganglion-cell-damage-peer-reviewed-article-OPTH-recommendation1